Mary Lyon Medal 2022 – Prof Irene Miguel-Aliaga

Irene Miguel-Aliaga is Professor of Genetics and Physiology at Imperial College London, and MRC Investigator at the MRC London Institute of Medical Sciences.

Irene has an interest in the crosstalk between organs – in particular, how and why the intestine communicates with other organs, such as the brain.  Her lab was one of the first to tackle the study of the brain-gut axis using the powerful genetics of Drosophila: work that they have now extended to mouse and human models.

Irene and her team discovered that the brain-gut axes of males and females are very different, and that these intestinal sex differences impact food intake, gamete production and tumour susceptibility.  They have also investigated how the intestine senses nutrients, revealing unexpected
roles for metal sensing in the regulation of feeding and growth.

Irene trained as a biochemist in Barcelona, Spain and she received her PhD in Genetics from the University of Oxford (UK).  She investigated how neurons develop during postdoctoral work at Harvard (USA), Linköping University (Sweden) and NIMR (now Crick Institute, UK).

Irene was the recipient of an ERC Starting Grant and currently holds an ERC Advanced Grant.  She was elected to the EMBO YIP programme in 2012, to EMBO in 2017 and to the Academy of Medical Sciences in 2019.  She was also awarded a Suffrage Science Women in Science award in 2018.