IMB/SFB 1361 Conference – Restore, Reorganise, Repurpose: The many faces of DNA repair

IMB/SFB 1361 Conference 20 September, 2022 - 23 September, 2022

Institute of Molecular Biology gGmbH, Ackermannweg 4, 55128 Mainz, Germany

Web Address


Deadline: 20/08/2022
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Submit your abstract here

General Information

DNA repair and damage response pathways provide essential defensive measures against insults to a cell’s genetic material. In this function, they protect and restore genome integrity by means of a variety of mechanisms adapted to a diverse set of lesions. However, DNA repair systems also critically impinge on other cellular processes. They contribute to accurate DNA replication, they help resolve conflicts arising from the presence of RNA in chromatin, and they are co-opted for gene regulatory purposes. The influence of DNA repair pathways on cell fate contributes to phenomena such as cancer and ageing. Finally, as genome maintenance mechanisms can prevent or promote mutagenesis, they are important regulators of evolution, as they modulate the genetic diversity that natural selection draws upon.

The 4-day conference, taking place at the Institute of Molecular Biology (IMB) in Mainz, will bring together leading scientists in the field of DNA repair, damage signalling and related research areas. It will focus on the diverse aspects of cellular metabolism that genome maintenance mechanisms impinge on, thereby approaching the classical “3R” (Replication – Recombination – Repair) theme from a new angle. It will feature sessions on maintaining the chemistry of DNA, taking care of breaks & ends, promoting genome replication, keeping RNA in check, controlling gene expression, modulating genome plasticity and ensuring healthy ageing.

Deadline for submissions: 20th July 2022

Meeting organisers:


Karlene Cimprich (Stanford University, US)

John Diffley (The Francis Crick Institute, London, UK)


Dana Branzei (IFOM, Milan, IT)

Cynthia Burrows (University of Utah, Salt Lake City, US)

Judith Campisi (Buck Institute for Research on Aging, Novato, US)

Karlene Cimprich (Stanford University, US)

John Diffley (The Francis Crick Insitute, London, UK)

Roger Greenberg (University of Pennsylvania,Philadelphia, US)

Natalia Gromak (University of Oxford, UK)

Petra Hajkova (MRC London Institute of Medical Sciences, UK)

Wolf-Dieter Heyer (University of California, US)

Tim Humphrey (University of Oxford, UK)

Puck Knipscheer (Hubrecht Institute, NL)

Sarah Lambert (Institute Curie, Paris, FR)

Laura Niedernhofer (University of Minnesota, Minneapolis, US)

Philippe Pasero (Université de Montpellier, FR)

KJ Patel (MRC Laboratory of Molecular Biology, Cambridge, UK)

Yves Pommier (National Cancer Insitut, Bethesda, US)

Julian Sale (MRC Laboratory of Molecular Biology, Cambridge, UK)

Björn Schumacher (CECAD Cologne/University of Cologne, DE)

Evi Soutoglou (University of Sussex, UK)

Zuzana Storchova (TU Kaiserslautern, DE)

Madalena Tarsounas (University of Oxford, UK)

Ben van Houten (University of Pittsburgh, US)