Science programme – Functional genetic variation in the non-coding genome

Thursday 10 November 2016

09:00 – 09:50 Registration with coffee

09:50 – 10:00 Meeting opening


Session I: Regulatory change, morphological and functional adaptation

Thursday 10 November 2016


10:00 – 10:40 Balfour Lecture 2016 – Felicity Jones (FML Max Plank Institute, Germany)

The molecular basis of adaptive trait changes and speciation in vertebrates


10:40 – 11:10 Eric Miska (Gurdon Institute, University of Cambridge, UK)

The genetics basis of non-coding variation in Cichlids

11:10 – 11:30 Peter Sarkies (MRC Clinical Sciences Centre, United Kingdom)

The Cost of Silence: Analysis of DNA methylation across nematodes reveals evolutionarily widespread off-target DNA alkylation damage associated with cytosine DNA methyltransferase activity

11:30 – 12:00 Coffee/Tea Break

12:00 – 12:30 Caroline Dean (John Innes Centre, UK)

Non-coding sequence variation influencing natural variation in vernalisation in Arabidopsis

12:30 – 12:50 Samuel Lewis (University of Cambridge, United Kingdom)

The evolution of arthropod small RNA pathways

12:50 – 14:00 Lunch and posters


Session II: Regulatory variation within species – disease and quantitative traits

Thursday 10 November 2016


14:00 – 14:30 Javier Caceres (MRC HGU, Edinburgh, UK)

Disease risk associated variation in miRNA sequence

14:30 – 14:50 Michelle Holland (Blizard Institute, Queen Mary University of London, United Kingdom)

Genetic variation at rDNA determines the epigenetic response to early life nutrition

14:50 – 15:20 Nuria Lopez-Bigas (University Pompeu Fabra, Barcelona, Spain)

Non-coding changes in cancer genomes

15:20 – 15:40 Lana Talmane (University of Edinburgh, United Kingdom)

The Landscape of Replication-Associated Mutations in Human and Mouse Germlines

15:40 – 16:10 Yang Li (Stanford University, USA)

Statistical genetics

16:10 – 16:40 Coffee/Tea Break

16:40 – 17:10 Anna Gloyn (Oxford Centre for Diabetes Endocrinology and Metabolism and the Wellcome Trust Centre for Human Genetics, Oxford, UK)

Genetic variation and type 2 diabetes/glycaemic traits mechanisms

17:10 – 17:30 Patrick Short (Wellcome Trust Sanger Institute, United Kingdom)

De novo mutations in highly conserved non-coding elements active in fetal brain contribute to severe neurodevelopmental disorders

17:30 – 17:50 Shipra Bhatia (University of Edinburgh, United Kingdom)

Decoding the functional significance of disease-associated regulatory variants in vivo

17:50 – 18:15 Genetics Society Annual General Meeting

18:15 – 19:30 Drinks and posters

19:30 Dinner


Session III: Postgraduate Symposium

Friday 11 November 2016

09:00 – 10:20 Student Talks

10:20 – 10:50 Coffee/Tea Break


Session IV: Decoding the grammar of the regulatory genome

Friday 11 November 2016


10:50 – 11:30 2016 Mary Lyon Medal – Duncan Odom (University of Cambridge, UK)

Evolution of gene regulation in vertebrate species


11:30 – 11:50 Roberto Simone (UCL, United Kingdom)

Rewiring MIR retrotransposons in long non-coding RNAs to regulate translation of paired antisense genes: the case of MAPT-AS1

11:50 – 12:20 Emma Farley (Princeton, USA)

Enhancers – less is more. Deleterious affects of mutating enhancers to higher affinity binding sites in Ciona

12:20 – 12:40 Yingguang Frank Chan (Friedrich Miescher Laboratory, Germany)

HybridMiX: Genetic mapping via mitotic recombinant “in vitro crosses” in interspecific mouse embryonic stem cells

12:40 – 13:40 Lunch and posters


Session V: – Systems approaches

Friday 11 November 2016


13:40 – 14:10 Barak Cohen (Washington University in St Louis, USA)

Computational decoding of enhancer grammar and experimental synthetic approaches

14:10 – 14:30 Vanessa Chong (Weatherall Institute of Molecular Medicine, United Kingdom)

“Biotagging” and ATAC-seq reveals gene regulatory logic for migratory neural crest identity encoded in the non-coding nuclear transcriptome

14:30 – 15:00 Daniel Bauer (Harvard, USA)

Enhancer bashing

15:00 – 15:20 Christoph Sadee (University College London, United Kingdom)

Statistical analysis of Saturation Transposon Mutagenesis in Fission Yest

15:20 – 15:50 Coffee/Tea Break

15:50 – 16:10 Tessa Bertozzi (University of Cambridge, United Kingdom)

Identification, characterization and inheritance of mammalian metastable epialleles


16:10 – 16:50 Balfour Lecture 2015 – Ben Lehner (Centre for Genomic Regulation, Barcelona, Spain)

Linking genotype to phenotype: The systems biology of gene regulation

16:50 Meeting Close